Because of mathematical indeterminancy and the uncertainty principle, it may be a law of nature that no nervous system is capable of acquiring enough knowledge to significantly predict the future of any other intelligent system in detail. Nor can intelligent minds gain enough self-knowledge to know their own future, capture fate, and in this sense eliminate free will.

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Piaget, who was originally trained as a biologist, views intellectual development as an interaction of an inherited genetic program with the environment. It is no coincidence that he calls this conception "genetic epistemology," in effect the study of the hereditary unfolding of understanding.