Eric Kandel Quotes

...in various types of organisms, from snails to flies to mice to people. ...learning and memory, as well as synaptic and neuronal plasticity, represent a family of processes that share a common logic and some key components but vary in the details of their molecular mechanisms.

CREB's opposing regulatory actions provide a threshold for memory storage, presumably to ensure that only important, life-serving experiences are learned. Repeated shocks to the tail are a significant learning experience for an Aplysia, just as, say, practicing the piano or conjugating French verbs are to us: practice makes perfect, repetition is necessary for long-term memory. In principle, however, a highly emotional state... could bypass the normal restraints on long-term memory. In such a situation, enough MAP kinase molecules would be sent into the nucleus rapidly enough to inactivate all of the CREB-2 molecules, thereby making it easy for protein kinase A to activate CREB-1 and put the experience directly into long-term memory.

Viennese life at the turn of the century provided opportunities in salons and coffeehouses for scientists, writers, and artists to come together in an atmosphere that was at once inspiring, optimistic, and politically engaged. ...science was no longer the narrow and restrictive province of scientists but had become an integral part of Viennese culture. ...a paradigm for how an open dialogue can be achieved.

In Vienna, Modernism had three main characteristics. The first was the new view of the human mind as being largely irrational by nature. ...they questioned what constitutes reality, what lies below the surface appearances of people, objects, and events. ...They discovered that ...people harbor not only unconscious erotic feelings, but also unconscious aggressive impulses that are directed against themselves as well as against others. Freud later called these dark impulses the death instinct.

I entered Harvard to become a historian and left to become a psychoanalyst, only to abandon both... to follow my intuition that the road to a real understanding of mind must pass through the cellular pathways of the brain.

The Age of Insight is a product of my subsequent fascination with the intellectual history of Vienna from 1890 to 1918, as well as my interest in Austrian modernist art, psychoanalysis, art history, and the brain science that is my life's work. In this book I examine the ongoing dialogue between art and science that had its origins in fin-de-siècle Vienna...

By merely observing the electrical activity in the brain, Libet could predict what a person would do before the person was actually aware of having decided to do it. This finding caused philosophers of mind to ask: If the choice is determined in the brain before we decide to act, where is free will? ...choice in action, as in perception, may reflect the importance of unconscious inference. Libet proposes that... just before the action is initiated, consciousness is recruited to approve or veto the action.

Unlike vision, touch, or smell, which are prewired and based on Kantian a priori knowledge, the spatial map presents us with a new type of representation, one based on a combination of a priori knowledge and learning. The general capability for forming spatial maps is built into the mind, but the particular map is not. Unlike neurons in a sensory system, place cells are not switched on by sensory stimulation. Their collective activity represents the location where the animal thinks it is.

Modernism began in the mid-nineteenth century as a response not only to the restrictions and hypocrisies of everyday life, but also as a reaction to the Enlightenment's emphasis on the rationality of human behavior. ...The founders of the Royal Society thought of God as a mathematician who had designed the universe according to logical and mathematical principles. The role of the scientist—the natural philosopher was to... decipher the codebook that God had used in creating the cosmos.

As knowledge advances and scientific disciplines change, so do the disciplines impinging on them.

I continue to explore the science in which I work almost like a child, with naïve joy, curiosity, and amazement.

The history of Austrian culture and scholarship in the modern era largely paralleled the history of Austrian Jewry.

The Viennese Kultusgemeinde... was going bankrupt... European governments typically compensate Jewish agencies... but the Austrian government's compensation was not adequate. ...I owe my existence in the United States to the generosity of the Viennese Kultusgemeinde.

Segregation occurs in the primary visual area of the cortex, which gives rise to two parallel pathways. ...the "what" pathway, carries information about the form of an object... the "where" pathway, carries information about the movement of the object in space: where the object is located.

Implicit memory is responsible not only for simple perceptual and motor skills but also, in principle, for the pirouettes of Margot Fonteyn, the trumpeting techniques of Wynton Marsalis, the accurate ground strokes of Andre Agassi, and the leg movements of an adolescent. Implicit memory guides us through well-established routines that are not consciously controlled.