The Age of Insight is a product of my... fascination with the intellectual history of Vienna from 1890 to 1918, as well as my interest in Austrian modernist art, psychoanalysis, art history, and the brain science that is my life's work. ...I examine the ongoing dialogue between art and science that had its origins in fin-de-siècle Vienna and document its three major phases.

Like other modern artists faced with the advent of the photography, Klimt sought newer truths that could not be captured by the camera. He... turned the artists view inward—away from the three-dimensional outside world and toward the multidimensional inner self and the unconscious mind.

The idea that we are unaware of much of out mental life, first developed by Hermann Helmholtz, is central to psychoanalysis. Freud has added the interesting idea that although we are not aware of most instances of mental processing, we can gain conscious access... by paying attention.

In the period from 1920 to 1960, psychiatry derived its main intellectual impetus from psychoanalysis. During this phase, its most powerful antidisciplines were philosophy and the social sciences. Since 1960, psychiatry has begun (again) to derive its main intellectual challenge from biology, with the result that neurobiology has been thrust into the position of the new antidiscipline for psychiatry.

Viennese life at the turn of the century provided opportunities in salons and coffeehouses for scientists, writers, and artists to come together in an atmosphere that was at once inspiring, optimistic, and politically engaged. ...science was no longer the narrow and restrictive province of scientists but had become an integral part of Viennese culture. ...a paradigm for how an open dialogue can be achieved.

The life of a biological scientist in the United States is a life of discussion and debate—it is the Talmudic tradition writ large. ...The egalitarian structure of American science encourages this camaraderie. ...this would not—could not—have taken place in the Austria, the Germany, the France, or perhaps even the England of 1955.

By merely observing the electrical activity in the brain, Libet could predict what a person would do before the person was actually aware of having decided to do it. This finding caused philosophers of mind to ask: If the choice is determined in the brain before we decide to act, where is free will? ...choice in action, as in perception, may reflect the importance of unconscious inference. Libet proposes that... just before the action is initiated, consciousness is recruited to approve or veto the action.

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Even though I had long been taught that the genes of the brain are the governors of behavior, the absolute masters of our fate, our work showed that, in the brain as in bacteria, genes are also servants of the environment. ...An environmental stimulus... activates modulatory interneurons that release serotonin. The serotonin acts on the sensory neuron to increase cyclic AMP and to cause protein kinase A and MAP kinase to move to the nucleus and activate CREB. The activation of CREB, in turn, leads to the expression of genes that changes the function and the structure of the cell.