It is not my place to tell you whether there is indefeasible ignorance of ultimate reality. I am ignorant of whether there is or is not. But you should think of these things because there are no things more important, though there are no questions more difficult or less answerable. But one's whole life may be changed if one changes his mind about these questions.
American philosopher (1913-1997)
Lewis White Beck (26 September, 1913 - 7 June, 1997) was an internationally recognized scholar and philosopher at the University of Rochester who specialized in the study of German Idealism and the philosophical writings of Immanuel Kant. His translation of Kant's Critique of Practical Reason was praised by many of his peers both in the United States and Germany. He also contributed to the founding of the North American Kant Society which fosters cooperative research into the works of Immanuel Kant internationally.
Bio from: Wikiquote (CC BY-SA 4.0)
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But somewhat like people who object to spending money needed in the ghettoes on exploring the moon, I think the best hope for our survival is to be based on understanding human predicaments here on earth, not expecting a saving message from super-human beings in the sky...Thinking about and even hoping to find extraterrestrial civilizations, however, sharpen our search for and appreciation of the peculiar virtues and vices of the only form of life we know.
For it is only in the Critique that all the various strands of Kant's thought are woven together into the pattern of his practical philosophy. This pattern, in turn, can be understood only in the entire fabric of the critical philosophy, and that rich design can be clear only to those who have understood each of its three principal parts, which are the three Critiques and not shorter and more popular works like the Prolegomena and the Foundations.