From the physical point of view the characteristic state of the living organism is that of an open system. A system is closed if no material enters or leaves it; it is open if there is import and export and, therefore, change of the components. Living systems are open systems, maintaining themselves in exchange of materials with environment, and in continuous building up and breaking down of their components.

(a) There is a general tendency towards integration in the various sciences, natural and social. (b) Such integration seems to be centered in a general theory of systems. (c) Such theory may be an important means of aiming at exact theory in the nonphysical fields of science. (d) Developing unifying principles running "vertically" through the universe of the individual sciences, this theory brings us nearer to the goal of the unity of sciences. (e) This can lead to a much needed integration in scientific education.

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Conventional physics deals only with closed systems, i.e. systems which are considered to be isolated from their environment... However, we find systems which by their very nature and definition are not closed systems. Every living organism is essentially an open system. It maintains itself in a continuous inflow and outflow, a building up and breaking down of components, never being, so long as it is alive, in a state of chemical and thermodynamic equilibrium but maintained in a so-called steady state which is distinct from the latter.

Systems thinking plays a dominant role in a wide range of fields from industrial enterprise and armaments to esoteric topics of pure science. Innumerable publications, conferences, symposia and courses are devoted to it. Professions and jobs have appeared in recent years which, unknown a short while ago, go under names such as systems design, systems analysis, systems engineering and others.

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Our civilization seems to be suffering a second curse of Babel: Just as the human race builds a tower of knowledge that reaches to the heavens, we are stricken by a malady in which we find ourselves attempting to communicate with each other in countless tongues of scientific specialization... The only goal of science appeared to be analytical, i.e., the splitting up of reality into ever smaller units and the isolation of individual causal trains...We may state as characteristic of modern science that this scheme of isolable units acting in one-way causality has proven to be insufficient. Hence the appearance, in all fields of science, of notions like wholeness, holistic, organismic, gestalt, etc., which all signify that, in the last resort, we must think in terms of systems of elements in mutual interaction..."

Science in the past (and partly in the present), was dominated by one-sided empiricism. Only a collection of data and experiments were considered as being ‘scientific’ in biology (and psychology); forgetting that a mere accumulation of data, although steadily piling up, does not make a science.