If the variables are continuous, this definition [Ashby’s fundamental concept of machine] corresponds to the description of a dynamic system by a set of ordinary differential equations with time as the independent variable. However, such representation by differential equations is too restricted for a theory to include biological systems and calculating machines where discontinuities are ubiquitous.

We are seeking for another basic outlook - the world as organization. This would profoundly change the categories of our thinking and influence our practical attitudes. We must envision the biosphere as a whole with mutually reinforcing or mutually destructive interdependencies.

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Our conception is that of a theory about the system in an inertial state... if the organism is a system in an inertial state, as our law expresses it, the metabolic processes generally have to follow the established system; the ever progressing findings must replace the general expression of 'a system in an inertial state' by a more and more detailed knowing about the nature of this system and its chemical, osmotic, fermentive system conditions.