Find out what really fascinates you and follow that. Almost anything in nature, if you follow it, you will find a scientific problem. That is a better way to do it than following fads, because what is fashionable today may have been solved or fallen out of fashion once you have become a working scientist.

You would have to ask a physicist really but I think understanding fundamental problems in physics is very important because they are part of our culture. You just never know what is going to come from it. If you had told Isaac Newton about spaceships and satellites that arise from his laws of gravity, it would have been science fiction to him.

If I had complained about the prize before I got mine, they may have thought I was anticipating sour grapes. But I complained on the grounds that too many important scientists get missed out for Nobels. Science today is a highly collaborative exercise and to convert it into a contest, as the Nobel does, is a bad way to look at science. On the other hand, I am grateful to the committee for my award. It put the study of ribosome – the cellular machine that turns the blueprint of life into life itself – on front pages round the world.

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It takes a certain amount of courage to tackle very hard problems in science, I now realise. You don't know what the timescale of your work will be: decades or only a few years. Or your approach may be fatally flawed and doomed to fail. Or you could get scooped just as you are finalising your work. It is very stressful.

I remember reading a Scientific American article about the use of new physical techniques – including neutron scattering – as a method for unravelling the structure of the ribosome. I was fascinated. I knew ribosomes were a big fundamental problem in science and this was a method for chipping away at it.

This is an honour that reflects the quality of science supported by the Medical Research Council, in particular at the Laboratory of Molecular Biology in Cambridge. In my case, credit should go to the numerous dedicated postdocs, students, associates and colleagues who made crucial contributions to the work.