I remember reading a Scientific American article about the use of new physical techniques – including neutron scattering – as a method for unravelling the structure of the ribosome. I was fascinated. I knew ribosomes were a big fundamental problem in science and this was a method for chipping away at it.

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It takes a certain amount of courage to tackle very hard problems in science, I now realise. You don't know what the timescale of your work will be: decades or only a few years. Or your approach may be fatally flawed and doomed to fail. Or you could get scooped just as you are finalising your work. It is very stressful.

Find out what really fascinates you and follow that. Almost anything in nature, if you follow it, you will find a scientific problem. That is a better way to do it than following fads, because what is fashionable today may have been solved or fallen out of fashion once you have become a working scientist.

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If I had complained about the prize before I got mine, they may have thought I was anticipating sour grapes. But I complained on the grounds that too many important scientists get missed out for Nobels. Science today is a highly collaborative exercise and to convert it into a contest, as the Nobel does, is a bad way to look at science. On the other hand, I am grateful to the committee for my award. It put the study of ribosome – the cellular machine that turns the blueprint of life into life itself – on front pages round the world.

This is an honour that reflects the quality of science supported by the Medical Research Council, in particular at the Laboratory of Molecular Biology in Cambridge. In my case, credit should go to the numerous dedicated postdocs, students, associates and colleagues who made crucial contributions to the work.

Indians tend to be a little insecure and they should stop being insecure — I have visited India many times and I can tell you questions I get after my talks are as perceptive as anywhere else in the world, including places like Harvard or MIT. It’s perfectly fine to take pride that someone from their region has used their background and succeeded. That gives them a positive message that they can do anything that they want.

Many in my family were ambivalent about it, but my mother encouraged me to put aside my fears. Vera (my wife) and I finally decided to leave Utah, where we were very happy, take a 40 per cent salary cut and move to the Laboratory of Molecular Biology at Cambridge.

Now many excellent scientists in India are doing really first rate work and it should not matter when the next Indian Nobel Prize is because they are doing very good work — that is what matters and the more you have this infrastructure, with good scientists within India, eventually someone will get a Nobel Prize for work done within India.

You would have to ask a physicist really but I think understanding fundamental problems in physics is very important because they are part of our culture. You just never know what is going to come from it. If you had told Isaac Newton about spaceships and satellites that arise from his laws of gravity, it would have been science fiction to him.

It’s not about where you were born, or where you come from that makes you a good scientist. What you need are good teachers, co-students, facilities, [he said]. I honestly don’t think my roots have much to do with it. I’m sure this won’t make me popular, but this is what I think.