It’s not about where you were born, or where you come from that makes you a good scientist. What you need are good teachers, co-students, facilities, [he said]. I honestly don’t think my roots have much to do with it. I’m sure this won’t make me popular, but this is what I think.

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This is an honour that reflects the quality of science supported by the Medical Research Council, in particular at the Laboratory of Molecular Biology in Cambridge. In my case, credit should go to the numerous dedicated postdocs, students, associates and colleagues who made crucial contributions to the work.

I remember reading a Scientific American article about the use of new physical techniques – including neutron scattering – as a method for unravelling the structure of the ribosome. I was fascinated. I knew ribosomes were a big fundamental problem in science and this was a method for chipping away at it.

There are already people who are world class in India, for example C.N.R. Rao (who has worked mainly in solid-state and structural chemistry). He is an example of how you can do first rate international work within India. So I would say to Indians — you have it within you to do this (in India).

This reconnection...has given me great satisfaction. I realise I have inadvertently become a source of inspiration and hope for people in India simply by the fact that I grew up there, went to my local university, but could go on to do well internationally. The Nobel, he says, is not just an affirmation of his past work; it’s an encouragement to keep working on interesting problems.

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Last year, the lecture was held in [an auditorium] with a capacity for just 300 people, and half the seats were empty. “What has changed? I am still the same person doing the same science. Why are people so impressed when some academy in Sweden gives an award?

Many in my family were ambivalent about it, but my mother encouraged me to put aside my fears. Vera (my wife) and I finally decided to leave Utah, where we were very happy, take a 40 per cent salary cut and move to the Laboratory of Molecular Biology at Cambridge.