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It takes a certain amount of courage to tackle very hard problems in science, I now realise. You don't know what the timescale of your work will be: decades or only a few years. Or your approach may be fatally flawed and doomed to fail. Or you could get scooped just as you are finalising your work. It is very stressful.

I remember reading a Scientific American article about the use of new physical techniques – including neutron scattering – as a method for unravelling the structure of the ribosome. I was fascinated. I knew ribosomes were a big fundamental problem in science and this was a method for chipping away at it.

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You would have to ask a physicist really but I think understanding fundamental problems in physics is very important because they are part of our culture. You just never know what is going to come from it. If you had told Isaac Newton about spaceships and satellites that arise from his laws of gravity, it would have been science fiction to him.

My own lab has two Chinese, a Malaysian, a Canadian, an American, a German, it has had all sorts of people. And it’s actually fun because people from different countries come together, they have cultural exchanges, they learn more about each others’ countries and way of life. Science is a great international mixer, so the idea that it is a sort of cricket match where our team won — that simply is a wrong way of looking at scientific discovery.

This is an honour that reflects the quality of science supported by the Medical Research Council, in particular at the Laboratory of Molecular Biology in Cambridge. In my case, credit should go to the numerous dedicated postdocs, students, associates and colleagues who made crucial contributions to the work.

Last year, the lecture was held in [an auditorium] with a capacity for just 300 people, and half the seats were empty. “What has changed? I am still the same person doing the same science. Why are people so impressed when some academy in Sweden gives an award?

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It’s not about where you were born, or where you come from that makes you a good scientist. What you need are good teachers, co-students, facilities, [he said]. I honestly don’t think my roots have much to do with it. I’m sure this won’t make me popular, but this is what I think.