A disruption of the circadian cycle — the metabolic and glandular rhythms that are central to our workaday life — seems to be involved in many, if no… - William Styron

The Consumers Union Report on Smoking was an aid to my stopping a two-pack-a-day habit which commenced in early infancy. For myself, after two or three days of great flaccidity of spirit, an aimless oral yearning, aching moments of hunger at the pit of the stomach, and an awful intermittent urge to burst into tears, the problem resolved itself, and in less than a week all craving vanished. Curiously, for the first time in my life, I developed a racking cough, but this, too, disappeared. A sense of smugness, a kind of fatness of soul, is the reward for such a struggle.

"On Major Depression, quoted by the great William Styron of Sophie's Choice & Darkness Visible:
From Darkness Visible, William Styron

"It is a positive and active anguish, a sort of psychical neuralgia, wholly unknown to normal life.

It is evil to keep these people in bondage, yet they cannot be freed. They must be educated! To free these people without education and with the prejudice that presently exists against them would be a ghastly crime.