He was alone with his thoughts. They were extremely unpleasant thoughts and he would rather have had a chaperon.
Douglas Adams, British science fiction writer and humorist (1952–2001)
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A disruption of the circadian cycle — the metabolic and glandular rhythms that are central to our workaday life — seems to be involved in many, if not most, cases of depression; this is why brutal insomnia so often occurs and is most likely why each day’s pattern of distress exhibits fairly predictable alternating periods of intensity and relief.
We should find perfect existence through imperfect existence. The basic teaching of Buddhism is the teaching of transiency, change. That everything changes is the basic truth of each existence. When we realize the everlasting truth of “everything changes” and find our composure in it, we find ourselves in Nirvana.
it has to be emphasized that if the pain were readily describable most of the countless sufferers from this ancient affliction would have been able to confidently depict for their friends and loved ones (even their physicians) some of the actual dimensions of their torment, and perhaps elicit a comprehension that has been generally lacking; such incomprehension has usually been due not to a failure of sympathy but to the basic inability of healthy people to imagine a form of torment so alien to everyday experience.