Once you start doubting, just like you’re supposed to doubt, you ask me if the science is true. You say no, we don’t know what’s true, we’re trying t… - Richard Feynman

So we have these wide principles which sweep across all the different laws, and if one takes too seriously its derivations, and feels that this is only valid because this [assumed more fundamental principle] is valid, you cannot understand the interconnections of the different branches of physics. Some day, when physics is complete, then maybe with this kind of argument we'll know all the laws, then we can start with some axioms (and no doubt somebody will figure out a particular way of doing it) and then all the deductions will be made. But while we don't know all the laws, we can use some to make guesses at theorems which extend beyond the proof.

"How can we tell whether the rules which we "guess" at are really right if we cannot analyze the game very well? There are, roughly speaking, three ways.

First, there may be situations where nature has arranged, or we arrange nature, to be simple and to have so few parts that we can predict exactly what will happen, and thus we can check how our rules work. (In one corner of the board there may be only a few chess pieces at work, and that we can figure out exactly.)

A second good way to check rules is in terms of less specific rules derived from them. For example, the rule on the move of a bishop on a chessboard is that it moves only on the diagonal. One can deduce, no matter how many moves may be made, that a certain bishop will always be on a red square. So, without being able to follow the details, we can always check our idea about the bishop's motion by finding out whether it is always on a red square. Of course it will be, for a long time, until all of a sudden we find that it is on a black square (what happened of course, is that in the meantime it was captured, another pawn crossed for queening, and it turned into a bishop on a black square). That is the way it is in physics. For a long time we will have a rule that works excellently in an over-all way, even when we cannot follow the details, and then some time we may discover a new rule. From the point of view of basic physics, the most interesting phenomena are of course in the new places, the places where the rules do not work — not the places where they do work! That is the way in which we discover new rules.

The third way to tell whether our ideas are right is relatively crude but prob-ably the most powerful of them all. That is, by rough approximation. While we may not be able to tell why Alekhine moves this particular piece, perhaps we can roughly understand that he is gathering his pieces around the king to protect it, more or less, since that is the sensible thing to do in the circumstances. In t

The first principle is that you must not fool yourself — and you are the easiest person to fool. So you have to be very careful about that. After you’ve not fooled yourself, it’s easy not to fool other scientists. You just have to be honest in a conventional way after that.