We can never know anything. - Werner Heisenberg

[S]ets of concepts... defined in physics. ...[F]our systems... have ...attained ...final form.
The first ...Newtonian mechanics ...for the description of all mechanical systems, ...motion of fluids and ...elastic ..; it comprises , , aerodynamics.
The second closed system of concepts... the theory of heat. Though... connected with mechanics through... statistical mechanics, it... [is] not... a part of mechanics. ...[T]he phenomenological theory of heat uses ...[some] concepts that have no [physics] counterpart ...like: , specific heat, entropy, free energy, etc. ...[F]rom ...phenomenological ...to a statistical interpretation ...considering heat as energy, distributed statistically among ...many degrees of freedom due to ...atomic structure... heat is no more connected with mechanics than with electrodynamics or other ...physics. The central concept ...is ...probability, closely connected with ...entropy ...Besides this ...the statistical theory of heat requires the concept of energy. But any coherent set ...in physics will ...contain ...concepts of energy, and and the law that these ...be conserved. This follows if the ...set is ...to describe ...features ...correct at all times and everywhere; ...[i.e.,] features that do not depend on space and time ...[i.e.,] are invariant under arbitrary translations in space and time, rotations in space and the Galileo— or Lorentz—transformation. Therefore, the theory of heat can be combined with any of the other closed systems of concepts.
The third... electricity and magnetism... reached... final form... through... Lorentz, Einstein and Minkowski. It comprises electrodynamics, special relativity, optics, magnetism, and one may include the de Broglie theory of s of all different sorts of elementary particles, but not the wave theory of Schrodinger.
[F]ourth... the quantum theory... Its central concept is the probability function, or... "statistical matrix"... It comprises quantum and wave mechanics, the theory of atomic spectra, chemistry, and the theory of other properties... like electric conductivity, , etc.
...The first set is contained in the third as the limiting case where the velocity of light can be considered as infinitely big, and is contained in the fourth as the limiting case where of action can be considered as infinitely small. The first and partly the third set belong to the fourth as a priori for the description of the experiments. The second set can be connected with any of the other three sets without difficulty and is especially important in its connection with the fourth. The independent existence of the third and fourth sets suggests the existence of a fifth set, of which one, three, and four are limiting cases. This fifth set will probably be found someday in connection with the theory of the elementary particles.

Can you, or anyone else, reach the central order of things or events, whose existence seems beyond doubt, as directly as you can reach the soul of another human being? I am using the term 'soul' quite deliberately so as not to be misunderstood. If you put your question like that, I would say yes. ... the word 'soul' refers to the central order, to the inner core of a being whose outer manifestations may be highly diverse and pass our understanding.

Only a few know, how much one must know to know how little one knows.