I am not so foolish as to equate what happens under the influence of mescalin or of any other drug, prepared or in the future preparable, with the realization of the end and ultimate purpose of human life: Enlightenment, the Beatific Vision. All I am suggesting is that the mescalin experience is what Catholic theologians call "a gratuitous grace," not necessary to salvation but potentially helpful and to be accepted thankfully, if made available. To be shaken out of the ruts of ordinary perception, to be shown for a few timeless hours the outer and the inner world, not as they appear to an animal obsessed with survival or to a human being obsessed with words and notions, but as they are apprehended, directly and unconditionally, by Mind at Large — this is an experience of inestimable value to everyone and especially to the intellectual.

The effects of mescalin or LSD can be, in some respects, far more satisfying than those of alcohol. To begin with, they last longer; they also leave behind no hangover, and leave the mental faculties clear and unimpaired. They stimulate the faculties and produce the ideal ground for a peak experience.

"I am not so foolish as to equate what happens under the influence of mescalin or of any other drug, prepared or in the future preparable, with the realization of the end and ultimate purpose of human life: Enlightenment, the Beatific Vision. All I am suggesting is that the mescalin experience is what Catholic theologians call "a gratuitous grace," not necessary to salvation but potentially helpful and to be accepted thankfully, if made available. To be shaken out of the ruts of ordinary perception, to be shown for a few timeless hours the outer and the inner world, not as they appear to an animal obsessed with survival or to a human being obsessed with words and notions, but as they are apprehended, directly and unconditionally, by Mind at Large — this is an experience of inestimable value to everyone and especially to the intellectual."

My own experience of mescalin is described in the appendix of Beyond the Outsider. My 'trip' was pleasant enough, although I experienced none of the visual effects described by Huxley; I was plunged into an agreeable but sluggish dreaminess. In this torpid state, I became aware of the problem mentioned by Huxley: 'How was this cleansed perception to be reconciled with a proper concern with human relations . . . ?' -- in my case, with my concern for my wife and three-year-old daughter? Although I personally felt nothing but a sense of relaxation and trustfulness, I was aware that, in practice, the world is full of dangers, and in this state, I was incapable of the necessary vigilance; it made me feel guilty. I was neglecting my job of looking after them. Moreover, my ability to think was impaired. Huxley remarks that he found his own ability to remember and 'think straight' to be little, if at all, reduced. I could 'think straight', but I could not think to any purpose. Even the feeling of universal love was not particularly pleasant; I compared it to having a large alsation dog who puts his paws on your shoulder and licks your face.

How significant is the enormous heightening, under mescalin, of the perception of color! ... Man's highly developed color sense is a biological luxury—inestimably precious to him as an intellectual and spiritual being, but unnecessary to his survival as an animal. ... Mescalin raises all colors to a higher power and makes the percipient aware of innumerable fine shades of difference, to which, at ordinary times, he is completely blind. It would seem that, for Mind at Large, the so-called secondary characters of things are primary.

When the brain runs out of sugar, the undernourished ego grows weak, can't be bothered to undertake the necessary chores, and loses all interest in those spatial and temporal relationships which mean so much to an organism bent on getting on in the world. As Mind at Large seeps past the no longer watertight valve, all kinds of biologically useless things start to happen. In some cases there may be extra-sensory perceptions. Other persons discover a world of visionary beauty. To others again is revealed the glory, the infinite value and meaningfulness of naked existence, of the given, unconceptualized event. In the final stage of egolessness there is an "obscure knowledge" that All is in all — that All is actually each. This is as near, I take it, as a finite mind can ever come to "perceiving everything that is happening everywhere in the universe."

The really important facts were that spatial relationships had ceased to matter very much and that my mind was perceiving the world in terms of other than spatial categories. At ordinary times the eye concerns itself with such problems as where? — how far? — how situated in relation to what? In the mescaline experience the implied questions to which the eye responds are of another order. Place and distance cease to be of much interest. The mind does its perceiving in terms of intensity of existence, profundity of significance, relationships within a pattern."

The really important facts were that spatial relationships had ceased to matter very much and that my mind was perceiving the world in terms of other than spatial categories. At ordinary times the eye concerns itself with such problems as where? — how far? — how situated in relation to what? In the mescaline experience the implied questions to which the eye responds are of another order. Place and distance cease to be of much interest. The mind does its perceiving in terms of intensity of existence, profundity of significance, relationships within a pattern.

“What about spatial relationships?” the investigator inquired, as I was looking at the books. It was difficult to answer. True, the perspective looked rather odd, and the walls of the room no longer seemed to meet in right angles. But these were not the really important facts. The really important facts were that spatial relationships had ceased to matter very much and that my mind was perceiving the world in terms of other than spatial categories. At ordinary times the eye concerns itself with such problems as Where?—How far?—How situated in relation to what? In the mescalin experience the implied questions to which the eye responds are of another order. Place and distance cease to be of much interest. The mind does its Perceiving in terms of intensity of existence, profundity of significance, relationships within a pattern. I saw the books, but was not at all concerned with their positions in space. What I noticed, what impressed itself upon my mind was the fact that all of them glowed with living light and that in some the glory was more manifest than in others. In this context position and the three dimensions were beside the point. Not, of course, that the category of space had been abolished. When I got up and walked about, I could do so quite normally, without misjudging the whereabouts of objects. Space was still there; but it had lost its predominance. The mind was primarily concerned, not with measures and locations, but with being and meaning.

I tried mescaline and cocaine in my youth, but I immediately switched to mint candy, which was more stimulating. I am not interested in drugs if they produce the same effects as alcohol. A drunkard is evidently ridiculous. I have been drunk some times, and I remember them as horrible experiences for me and everyone else.

Anything that gets the adrenalin moving like a 440 volt blast in a copper bathtub is good for the reflexes and keeps the veins free of cholesterol... but too many adrenaline rushes in any given time span has the same effect on the nervous system as too many electro-shock treatments are said to have on the brain: after a while you start burning out the circuits. When a jackrabbit gets addicted to road-running, its only a matter of time before he gets smashed — and when a journalist turns into a politics junkie he will sooner or later start raving and babbling in print about things that only a person who has Been There can possibly understand.

In addition, recent neuroimaging studies of people under the influence of psychedelic drugs have shown that the elaborate mystical experiences associated with these drugs are accompanied by decreased brain activity.

I took my [mescaline] pill at eleven ... I spent several minutes – or was it several centuries? – not merely gazing at those bamboo legs, but actually being them – or rather being myself in them; or, to be still more accurate (for "I" was not involved in the case, nor in a certain sense were "they") being my Not-self in the Not-self which was the chair.

[After the mercury poisoning (cited above)] I have cognitive problems, clearly [...] I have short-term memory loss, and I have longer-term memory loss that affects me.