I am not so foolish as to equate what happens under the influence of mescalin or of any other drug, prepared or in the future preparable, with the realization of the end and ultimate purpose of human life: Enlightenment, the Beatific Vision. All I am suggesting is that the mescalin experience is what Catholic theologians call "a gratuitous grace," not necessary to salvation but potentially helpful and to be accepted thankfully, if made available. To be shaken out of the ruts of ordinary perception, to be shown for a few timeless hours the outer and the inner world, not as they appear to an animal obsessed with survival or to a human being obsessed with words and notions, but as they are apprehended, directly and unconditionally, by Mind at Large — this is an experience of inestimable value to everyone and especially to the intellectual.

"I am not so foolish as to equate what happens under the influence of mescalin or of any other drug, prepared or in the future preparable, with the realization of the end and ultimate purpose of human life: Enlightenment, the Beatific Vision. All I am suggesting is that the mescalin experience is what Catholic theologians call "a gratuitous grace," not necessary to salvation but potentially helpful and to be accepted thankfully, if made available. To be shaken out of the ruts of ordinary perception, to be shown for a few timeless hours the outer and the inner world, not as they appear to an animal obsessed with survival or to a human being obsessed with words and notions, but as they are apprehended, directly and unconditionally, by Mind at Large — this is an experience of inestimable value to everyone and especially to the intellectual."

Aldous Huxley took the drug mescaline and then chronicled his experience in the book The Doors of Perception. Now, I don't actually think that's the first thing he wrote: he probably wrote 'my brain is melting' ten thousand times, but it was the book that the critics latched on to.

How significant is the enormous heightening, under mescalin, of the perception of color! ... Man's highly developed color sense is a biological luxury—inestimably precious to him as an intellectual and spiritual being, but unnecessary to his survival as an animal. ... Mescalin raises all colors to a higher power and makes the percipient aware of innumerable fine shades of difference, to which, at ordinary times, he is completely blind. It would seem that, for Mind at Large, the so-called secondary characters of things are primary.

These effects of mescalin are the sort of effects you could expect to follow the administration of a drug having the power to impair the efficiency of the cerebral reducing valve. When the brain runs out of sugar, the undernourished ego grows weak, can't be bothered to undertake the necessary chores, and loses all interest in those spatial and temporal relationships which mean so much to an organism bent on getting on in the world. As Mind at Large seeps past the no longer watertight valve, all kinds of biologically useless things start to happen. ... Other persons discover a world of visionary beauty. To others again is revealed the glory, the infinite value and meaningfulness of naked existence, of the given, unconceptualized event.

The really important facts were that spatial relationships had ceased to matter very much and that my mind was perceiving the world in terms of other than spatial categories. At ordinary times the eye concerns itself with such problems as where? — how far? — how situated in relation to what? In the mescaline experience the implied questions to which the eye responds are of another order. Place and distance cease to be of much interest. The mind does its perceiving in terms of intensity of existence, profundity of significance, relationships within a pattern."

The really important facts were that spatial relationships had ceased to matter very much and that my mind was perceiving the world in terms of other than spatial categories. At ordinary times the eye concerns itself with such problems as where? — how far? — how situated in relation to what? In the mescaline experience the implied questions to which the eye responds are of another order. Place and distance cease to be of much interest. The mind does its perceiving in terms of intensity of existence, profundity of significance, relationships within a pattern.

“What about spatial relationships?” the investigator inquired, as I was looking at the books. It was difficult to answer. True, the perspective looked rather odd, and the walls of the room no longer seemed to meet in right angles. But these were not the really important facts. The really important facts were that spatial relationships had ceased to matter very much and that my mind was perceiving the world in terms of other than spatial categories. At ordinary times the eye concerns itself with such problems as Where?—How far?—How situated in relation to what? In the mescalin experience the implied questions to which the eye responds are of another order. Place and distance cease to be of much interest. The mind does its Perceiving in terms of intensity of existence, profundity of significance, relationships within a pattern. I saw the books, but was not at all concerned with their positions in space. What I noticed, what impressed itself upon my mind was the fact that all of them glowed with living light and that in some the glory was more manifest than in others. In this context position and the three dimensions were beside the point. Not, of course, that the category of space had been abolished. When I got up and walked about, I could do so quite normally, without misjudging the whereabouts of objects. Space was still there; but it had lost its predominance. The mind was primarily concerned, not with measures and locations, but with being and meaning.

I profoundly admire Aldous Huxley, both for his philosophy and uncompromising sincerity. But I disagree with his advocacy of 'the chemical opening of doors into the Other World', and with his belief that drugs can procure 'what Catholic theologians call a gratuitous grace'. Chemically induced hallucinations, delusions and raptures may be frightening or wonderfully gratifying; in either case they are in the nature of confidence tricks played on one's own nervous system.

The effects of mescalin or LSD can be, in some respects, far more satisfying than those of alcohol. To begin with, they last longer; they also leave behind no hangover, and leave the mental faculties clear and unimpaired. They stimulate the faculties and produce the ideal ground for a peak experience.

In a 1940 letter Aldous Huxley said that although he was profoundly pessimistic about collective humanity at the moment, he was "profoundly optimistic about individuals and groups of individuals existing on the margins of society." The British author, living in Los Angeles, was the hub of a kind of pre-Aquarian conspiracy, an international network of intellectuals, artists, and scientists interested in the notion of transcendence and transformation. They disseminated new ideas, supported each other's efforts, and wondered whether anything would ever come of it. Many of Huxley's interests were so advanced that they did not come into their own until the decade after his death. When such ideas were heresies, he was a proponent of consciousness research, decentralization in government and the economy, paranormal healing, the uses of altered awareness, visual retraining, and acupuncture.

Aldous Huxley did his best to argue us out of the view that a chemically conditioned spiritual experience is false—and he did so long before we knew anything about cannabinoid or opioid receptor networks….He points out that mystics have always worked systematically to modify their brain chemistry, whether through fasting, self-flagellation, sleeplessness, hypnotic movement, or chanting.†
†Huxley suggests that the reason there aren’t nearly as many mystics and visionaries walking around today, as compared to the Middle Ages, is the improvement in nutrition. Vitamin deficiencies wreak havoc on brain function and probably explain a large portion of visionary experiences in the past.

European soldiers, traders, missionaries - later on ably assisted by its colonial ideologies and scholars - opened up the East to the influences of the West. But Huxley belonged to that small group of European thinkers and seekers who opened up the West to the influence of the East - a more arduous task and in the long run perhaps more important too. He did not seek this role, it was merely a bye-product of his search for truth. Huxley was one of the finest products of Europe - of a new Europe seeking its old roots, of a Europe no longer satisfied with mere technology and science and rationality but seeking a new dimension of the spirit, a Europe self-critical and in search. He was also a profound student of Europe's various traditions, religious, literary and artistic, and he discusses them with great knowledge, insights, authority and intimacy. In his hands, cultural Europe becomes alive. A critical discussion of Europe by such a sympathetic insider is meant to help, to fecundate; it can do no harm but will only help Europe in its spiritual rediscovery. In opening up to India and China, it would merely be opening up to an ancient tradition which was lost by her but preserved and developed in India and China.

"We suffer from a hallucination, from a false and distorted sensation of our own existence as living organisms. Most of us have the sensation that "I myself" is a separate center of feeling and action, living inside and bounded by the physical body — a center which "confronts" an "external" world of people and things, making contact through the senses with a universe both alien and strange."