Although analytic philosophers have said much about suicide, their focus has been almost exclusively on the question whether suicide is ever morally permissible, as distinct from whether there is ever something stronger to be said in its favor. Moreover, most (but not all) such philosophical writing considers this question within the context of terminal disease or unbearable and intractable (usually physical) suffering. For some, these are the only bases for suicide that are even worthy of discussion. Others are prepared to extend the discussion to a limited range of other cases, such as those involving irreversible loss of dignity. Suicide on any other grounds, according to this view, must surely be wrong. I take this view to be mistaken. We cannot preclude the possibility that somebody’s life may become unacceptably burdensome to him even though his death is not already imminent and he is not suffering the most extreme and intractable physical pain or irreversible loss of dignity.

A fourth way in which suicide is criticized is by claiming that it is a cowardly act. The idea is that the person who kills himself lacks the courage to face life’s burdens and thus “takes the easy way out.” Courage, on this view, requires standing one’s ground in the face of life’s adversities and bearing them with fortitude. One way to respond to this criticism is to deny that accepting life’s burdens is always courageous. This will seem odd to those who have a crude conception of courage according to which the unswerving, fearless response to adversity is always courageous. More sophisticated accounts of courage, however, recognize that a steely response may sometimes be a failing. This is what lies behind the adage that sometimes “discretion is the better part of valor.” On the more sophisticated views, too much bravado ceases to be courageous and is instead foolhardiness or even foolishness. Once we recognize that courage should not be confused with its simulacra, the possibility arises that some of life’s burdens may be so great and the point of bearing them so tenuous that enduring them further is not courageous at all and may even be foolish.

Humans may exceed other animals in their sapient capacities, but we also surpass other species on our destructiveness. Many animals cause harm, but we are the most lethal species ever to have inhabited our planet. It is revealing that we do not refer to this superlative property in identifying ourselves. There is ample evidence that we are Homo pernicious – the dangerous, destructive human.

Few prospective procreators consider the aesthetic impact of their potential children. But how many more producers of excrement and urine, flatulence, menstrual blood and semen, sweat, mucus, vomit, and pus do we really need? How much more human waste do we need to process? How many more corpses do we need to dispose of? It would be an aesthetic improvement if there were fewer people.

Life's big questions are big in the sense that they are momentous. However, contrary to appearances, they are not big in the sense of being unanswerable. It is only that the answers are generally unpalatable. There is no great mystery, but there is plenty of horror.

Although, as we have seen, nobody is lucky enough not to be born, everybody is unlucky enough to have been born – and particularly bad luck it is, as I shall now explain. On the quite plausible assumption that one’s genetic origin is a necessary (but not sufficient) condition for having come into existence, one could not have been formed by anything other than the particular gametes that produced the zygote from which one developed. This implies, in turn, that one could not have had any genetic parents other than those that one does have. It follows from this that any person’s chances of having come into existence are extremely remote. The existence of any one person is dependent not only on that person’s parents themselves having come into existence and having met but also on their having conceived that person at the time that they did. Indeed, mere moments might make a difference to which particular sperm is instrumental in a conception. The recognition of how unlikely it was that one would have come into existence, combined with the recognition that coming into existence is always a serious harm, yields the conclusion that one’s having come into existence is really bad luck. It is bad enough when one suffers some harm. It is worse still when the chances of having been harmed are very remote.

Things are also stacked against us in the fulfillment of our desires and the satisfaction of our preferences. Many of our desires are never fulfilled. There are thus more unfulfilled than fulfilled desires. Even when desires are fulfilled, they are not fulfilled immediately. Thus, there is a period during which those desires remain unfulfilled. Sometimes, that is a relatively short period (such as between thirst and, in ordinary circumstances, its quenching), but in the case of more ambitious desires, they can take months, years, or decades to fulfill. Some desires that are fulfilled prove less satisfying than we had imagined. One wants a specific job or to marry a particular person, but upon attaining one’s goal, one learns that the job is less interesting or the spouse is more irritating than one thought. Even when fulfilled desires are everything that they were expected to be, the satisfaction is typically transitory, as the fulfilled desires yield to new desires. Sometimes, the new desires are more of the same. For example, one eats to satiety but then hunger gradually sets in again and one desires more food. The “treadmill of desires” works in another way too. When one can regularly satisfy one’s lower-level desires, a new and more demanding level of desires emerges. Thus, those who cannot provide for their own basic needs spend their time striving to fulfill these. Those who can satisfy the recurring basic needs develop what Abraham Maslow calls a “higher discontent” that they seek to satisfy. When that level of desires can be satisfied, the aspirations shift to a yet higher level. Life is thus a constant state of striving. There are sometimes reprieves, but the striving ends only with the end of life. Moreover, as should be obvious, the striving is to ward off bad things and attain good things. Indeed, some of the good things amount merely to the temporary relief from the bad things. For example, one satisfies one’s hunger or quenches one’s thirst. Notice too that while the bad things come without any effort, one has to strive to ward them off and attain the good things. Ignorance, for example, is effortless, but knowledge usually requires hard work.

Our lives contain so much more bad than good in part because of a series of empirical differences between bad things and good things. For example, the most intense pleasures are short-lived, whereas the worst pains can be much more enduring. Orgasms, for example, pass quickly. Gastronomic pleasures last a bit longer, but even if the pleasure of good food is protracted, it lasts no more than a few hours. Severe pains can endure for days, months, and years. Indeed, pleasures in general—not just the most sublime of them—tend to be shorter-lived than pains. Chronic pain is rampant, but there is no such thing as chronic pleasure. There are people who have an enduring sense of contentment or satisfaction, but that is not the same as chronic pleasure. Moreover, discontent and dissatisfaction can be as enduring as contentment and satisfaction; this means that the positive states are not advantaged in this realm. Indeed, the positive states are less stable because it is much easier for things to go wrong than to go right. The worst pains are also worse than the best pleasures are good. Those who deny this should consider whether they would accept an hour of the most delightful pleasures in exchange for an hour of the worst tortures. Arthur Schopenhauer makes a similar point when he asks us to “compare the respective feelings of two animals, one of which is engaged in eating the other.” The animal being eaten suffers and loses vastly more than the animal that is eating gains from this one meal. Consider too the temporal dimensions of injury or illness and recovery. One can be injured in seconds: One is hit by a bullet or projectile, or is knocked over or falls, or suffers a stroke or heart attack. In these and other ways, one can instantly lose one’s sight or hearing or the use of a limb or years of learning. The path to recovery is slow. In many cases, full recovery is never attained. Injury comes in an instant, but the resultant suffering can last a lifetime. Even lesser injuries and illnesses are typically incurred much more quickly than one recovers from them. For example, the common cold strikes quickly and is defeated much more slowly by one’s immune system. The symptoms manifest with increasing intensity within hours, but they take at least days, if not weeks, to disappear entirely.

The question is not whether humans will become extinct, but rather when they will. If the anti-natalist arguments are correct, it would be better, all things being equal, if this happened sooner rather than later for, the sooner it happens, the more suffering and misfortune will be avoided.

If we take a cold, hard look at the human condition, we see an unpleasant picture. However, there are powerful biological drives against fully recognizing the awfulness of the human predicament that explain why so many people succeed in putting it out of their minds for much of the time. This is a mixed blessing. Ignorance is an existential analgesic, but those who do not sufficiently feel the weight of the human predicament are also vectors for its transmission to new generations.

[T]he overwhelming urge to repeat the optimistic messages, especially in the bleakest times, suggests that they are not quite reassuring enough. It is as if the repetition of the “good news” is essential because it is so at odds with the way the world seems to be. While the optimists have answers to life’s big questions, they are not the right ones, or so I shall argue. Their answers are believed, when they are believed, because people so desperately want to believe them, and not because the force of arguments supporting them makes it the case that we must believe them.

Life is meaningless, but it also has meaning—or, more accurately, meanings. There is no such thing as the meaning of life. Many different meanings are possible. One can transcend the self and make a positive mark on the lives of others in myriad ways. These include nurturing and teaching the young, caring for the sick, bringing relief to the suffering, improving society, creating great art or literature, and advancing knowledge. We are nonetheless warranted in regretting our cosmic insignificance and the pointlessness of the entire human endeavor. As impressed as (some) humans often are about the significance of humanity’s presence in the cosmos, our absence would have made absolutely no difference to the rest of the universe. We serve no purpose in the cosmos and, although our efforts have some significance here and now, it is seriously limited both spatially and temporally. Even those who think that we ought not to yearn for the greater meaning that is unattainable must recognize the immense tragedy of beings who suffer such existential anxiety over their insignificance. That suffering is indisputably a part of the human predicament.

A pessimistic book is most likely to bring some solace to those who already have those views but who feel alone or pathological as a result. They may gain some comfort from recognizing that there are others who share their views and that these views are supported by good arguments.

Assuming that each couple has three children, an original pair's cumulative descendants over ten generations amount to 88,572 people. That constitutes a lot of pointless, avoidable suffering. To be sure, full responsibility for it all does not lie with the original couple because each new generation faces the choice of whether to continue that line of descendants. Nevertheless, they bear some responsibility for the generations that ensue. If one does not desist from having children, one can hardly expect one's descendants to do so.