Of the three great skeptics I interviewed, Popper was the first to make his mark. His philosophy stemmed from his effort to distinguish pseudoscience, such as Marxism or astrology or Freudian psychology, from genuine science, such as Einstein's theory of relativity. The latter, Popper decided, was testable; it made predictions about the world that could be empirically checked. The logical positivists had said as much. But Popper denied the positivist assertion that scientists can prove a theory through induction, or repeated empirical tests or observations. One never knows if one's observations have been sufficient; the next observation might contradict all that preceded it. Observations can never prove a theory but can only disprove, or falsify it. Popper often bragged that he had "killed" logical positivism with this argument.

By the time I was 11 or so Catholicism stopped making sense. Why, if God loves us, would He inflict hell on us, just for skipping mass now and then? That doctrine, which hard-eyed nuns taught in catechism, seemed awfully harsh. Also, I couldn’t imagine how heaven could fail to be boring. Like lots of young people in my generation (I graduated from high school in 1971), I began checking out more exotic religions. I became intrigued by enlightenment, the goal of Hinduism and Buddhism. I envisioned it as a state of supreme bliss and wisdom. It’s like heaven, except you don’t have to die to get there. Seeking enlightenment, I learned meditation and yoga and ingested psychedelics, and I read Doors of Perception by Aldous Huxley and Siddhartha by Hermann Hesse. Far from enlightening me, my forays into mysticism deepened my sense of weirdness.

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These are extraordinary events. Not measured before, not contemplated before. [the extreme weather events of 2021 will lead to a host of initiatives to help communities adapt in the future] but there was nothing, nothing that could have been done [to prepare for] a three-times-the-historic-high volume of water travelling through Merritt in one day.

Science has only existed for a few hundred years, and its most spectacular achievements have occurred within the last century. Viewed from a historical perspective, the modern era of rapid scientific and technological progress appears to be not a permanent feature of reality, but an abberation, a fluke, a product of a singular convergence of social, intellectual, and political factors.

Between sessions at a physics conference, I asked a number of attendees: Who is the smartest physicist of them all? ...the name mentioned most often was Witten's. He seemed to evoke a special kind of awe, as though he belonged to a category unto himself. He is often likened to Einstein; one colleague reached even further back for a comparison, suggesting that Witten possessed the greatest mathematical mind since Newton.

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Einstein had drawn attention to nonlocality in 1935 in an effort to show that quantum mechanics must be flawed. ...Einstein proposed a thought experiment—now called the EPR experiment—involving two particles that spring from a common source and fly in opposite directions.
According to the standard model of quantum mechanics, neither particle has a definite position or momentum before it is measured; but by measuring the momentum of one particle, the physicist instantaneously forces the other particle to assume a fixed position... Deriding this effect as "spooky action at a distance," Einstein argued that it violated both common sense and his own theory of special relativity, which prohibits the propagation of effects faster than the speed of light; quantum mechanics must therefore be an incomplete theory. In 1980, however, a group of French physicists carried out a version of the EPR experiment and showed that it did indeed give rise to spooky action. (The reason that the experiment does not violate special relativity is that one cannot exploit nonlocality to transmit information.)

Popper scoffs at scientists’ hope that they can achieve a final theory of nature. "...I think we have gone very far, but we are much further away." He... returns with his book Conjectures and Refutations. ...[H]e reads his own words with reverence: "In our infinite ignorance we are all equal."

Over the last few decades, physics in the grand mode practiced by Hawking and Rees has become increasingly disconnected from empirical evidence. Proponents of string and multiverse models tout their mathematical elegance, but strings are too small and multiverses too distant to be detected by any plausible experiment.

In Theories of Everything... John Barrow argued that Gödel's incompleteness theorem undermines the very notion of a complete theory of nature. Gödel established that any moderately complex system of axioms inevitably raises questions that cannot be answered about the axioms. The implication is that any theory will always have loose ends. Barrow also pointed out that a unified theory of particle physics would not really be a theory of everything, but only a theory of all particles and forces. The theory would have little or nothing to say about phenomena that make our lives meaningful, such as love or beauty.

Of course, the apparent disarray could have stemmed entirely from my own ignorance. But when I revealed my impression of confusion and dissonance to one of the attendees, he reassured me that my perception was accurate. “It’s a mess,” he said of the conference (and, by implication, the whole business of interpreting quantum mechanics). The problem, he noted, arose because, for the most part, the different interpretations of quantum mechanics cannot be empirically distinguished from one another; philosophers and physicists favor one interpretation over another for aesthetic and philosophical—that is, subjective—reasons.

Kuhn's recognition that science might cease—leaving us with what Charles Sanders Peirce had defined as the "truth" about nature—made it even more imperative for Kuhn than for Popper to challenge science's authority, to deny that science can ever arrive at absolute truth. "The one thing I think you shouldn't say is that now we've found out what the world is really like," Kuhn said. "Because that's not what I think the game is about."

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