Uncertainty also relieves us of our judgment of ourselves. Then we don’t know if we’re lovable or not; we don’t know how attractive we are; we don’t know how successful we could potentially become. The only way to achieve these things is to remain uncertain of them and be open to finding them out through experience. Uncertainty is the root of all progress and all growth. As the old adage goes, the man who believes he knows everything learns nothing. We cannot learn anything without first not knowing something.

Abandon certainty! That's life's deepest command. That's what life's all about. We're a probe into the unknown, into the uncertain. Why can't you hear Muad'Dib? If certainty is knowing absolutely an absolute future, then that's only death disguised! Such a future becomes now!

Everything changed, and it went right on changing. A terrible thought when things were good, a comforting one now. Whatever happened, she could be certain that things wouldn’t stay the way they were now. And if she stayed smart and clever and lucky, she’d be able to affect how the next change came. Or take advantage of it.

You never really know how or when your life is going to change, and that's for the best.

Uncertainty removes our judgments of others; it preempts the unnecessary stereotyping and biases that we otherwise feel when we see somebody on TV, in the office, or on the street. Uncertainty also relieves us of our judgment of ourselves. We don’t know if we’re lovable or not; we don’t know how attractive we are; we don’t know how successful we could potentially become. The only way to achieve these things is to remain uncertain of them and be open to finding them out through experience.

It’s the backwards law again: the more you try to be certain about something, the more uncertain and insecure you will feel. But the converse is true as well: the more you embrace being uncertain and not knowing, the more comfortable you will feel in knowing what you don’t know.

I will never be a brain surgeon, and I will never play the piano like Glenn Gould.

But what keeps me up late at night, and constantly gives me reason to fret, is this: I don’t know what I don’t know. There are universes of things out there — ideas, philosophies, songs, subtleties, facts, emotions — that exist but of which I am totally and thoroughly unaware. This makes me very uncomfortable. I find that the only way to find out the fuller extent of what I don’t know is for someone to tell me, teach me or show me, and then open my eyes to this bit of information, knowledge, or life experience that I, sadly, never before considered.

Afterward, I find something odd happens. I find what I have just learned is suddenly everywhere: on billboards or in the newspaper or SMACK: Right in front of me, and I can’t help but shake my head and speculate how and why I never saw or knew this particular thing before. And I begin to wonder if I could be any different, smarter, or more interesting had I discovered it when everyone else in the world found out about this particular obvious thing. I have been thinking a lot about these first discoveries and also those chance encounters: those elusive happenstances that often lead to defining moments in our lives.

[…]

I once read that the definition of insanity is doing the same thing over and over and expecting different results. I fundamentally disagree with this idea. I think that doing the same thing over and over and expecting different results is the definition of hope. We might keep making mistakes but the struggle gives us a sense of empathy and connectivity that we would not experience otherwise. I believe this empathy improves our ability to see the unseen and better know the unknown.

Lives are shaped by chance encounters and by discovering things that we don’t know that we don’t know. The arc of a life is a circuitous one. … In the grand scheme of things, everything we do is an experiment, the outcome of which is unknown.

The only thing constant in life is change

That tide of insecurity would come in and out over the years, sometimes stranding me for a while but occasionally lifting me just beyond what I thought I could accomplish. Either way, it would wash over the same bedrock certainty: ultimately, I know myself. At each stage of my life, I've had a pretty clear notion of my needs and of what I was ready for.

There are some things that you know to be true, and others that you know to be false; yet, despite this extensive knowledge that you have, there remain many things whose truth or falsity is not known to you. We say that you are uncertain about them. You are uncertain, to varying degrees, about everything in the future; much of the past is hidden from you; and there is a lot of the present about which you do not have full information. Uncertainty is everywhere and you cannot escape from it.

But in my professional life, I have learned to accept uncertainty and even embrace it.

The only thing you can count on for certain is change. Don't wait for it -be an agent of change. Help bring change about.

View change as the one constant in your life. Welcome it. Expect it. Anticipate it.

"The unknown," said Faxe's soft voice in the forest, "the unforetold, the unproven, that is what life is based on. Ignorance is the ground of thought. Unproof is the ground of action. If it were proven that there is no God there would be no religion. No Handdara, no Yomesh, no hearthgods, nothing. But also if it were proven that there is a God, there would be no religion. ... Tell me, Genry, what is known? What is sure, unpredictable, inevitable — the one certain thing you know concerning your future, and mine?"

That we shall die."

Yes, There's really only one question that can be answered, Genry, and we already know the answer. ... The only thing that makes life possible is permanent, intolerable uncertainty: not knowing what comes next."