To make a huge success, a scientist must be prepared to get into deep trouble. Sometime or another, someone will tell you that you are not ready to do something. … If you are going to make a big jump in science, you will very likely be unqualified to succeed by definition. The truth, however, won't save you from criticism. Your very willingness to take on a very big goal will offend some people who will think that you are too big for your britches and crazy to boot.

One could not be a successful scientist without realizing that, in contrast to the popular conception supported by newspapers and mothers of scientists, a goodly number of scientists are not only narrow-minded and dull, but also just stupid.

The less somebody knows and understands himself the less great he is, however great may be his talent. For this reason our scientists are not great.

The man of science who commits himself to even one statement which turns out to be devoid of good foundation loses somewhat of his reputation among his fellows, and if he be guilty of the same error often he loses not only his intellectual, but his moral standing among them. For it is justly felt that errors of this kind have their root rather in the moral than in the intellectual nature.

We had the freedom to make mistakes. That's something very important. Unfortunately, this freedom for scientists gets more and more lost. … Otherwise, you do the common things. You don't dare to do something beyond what everybody else thinks.

There is no worse calamity for science and for scholarship than those intruders who are foreign to them. They are ignorant and yet think they know; they ruin everything whilst convinced they are fixing all.

Scientists are not known for the graces of courtesy and tact when commenting on the work of others.

If they leave college thinking, as they usually do, that science offers a full, accurate, and literal description of man and Nature; if they think scientific research by itself yields final answers to social problems; if they think scientists are the only honest, patient, and careful workers in the world; if they think that Copernicus, Galileo, Newton, Lavoisier, and Faraday were unimaginative plodders like their own instructors; if they think theories spring from facts and that scientific authority at any time is infallible; if they think that the ability to write down symbols and read manometers is fair grounds for superiority and pride, and if they think that science steadily and automatically makes for a better world — then they have wasted their time in the science lecture room; they live in an Ivory Laboratory more isolated than the poet's tower, and they are a plain menace to the society they belong to. They are a menace whether they believe all this by virtue of being engaged in scientific work themselves or of being disqualified from it by felt or fancied incapacity.'''

Why do we put up with it? Do we like to be criticized? No, no scientist enjoys it. Every scientist feels a proprietary affection for his or her ideas and findings. Even so, you don’t reply to critics, Wait a minute; this is a really good idea; I’m very fond of it; it’s done you no harm; please leave it alone. Instead, the hard but just rule is that if the ideas don’t work, you must throw them away.

One of the characteristics of successful scientists is having courage. Once you get your courage up and believe that you can do important problems, then you can. If you think you can't, almost surely you are not going to. [...] The average scientist, so far as I can make out, spends almost all his time working on problems which he believes will not be important and he also doesn't believe that they will lead to important problems. [...] In summary, I claim that some of the reasons why so many people who have greatness within their grasp don't succeed are: they don't work on important problems, they don't become emotionally involved, they don't try and change what is difficult to some other situation which is easily done but is still important, and they keep giving themselves alibis why they don't.

Scientists are just as vulnerable to wishful thinking, just as likely to be tempted by base motives, just as venal and gullible and forgetful as the rest of humankind. Scientists don't consider themselves to be saints; they don't even pretend to be priests (who according to tradition are supposed to do a better job than the rest of us at fighting off human temptation and frailty). Scientists take themselves to be just as weak and fallible as anybody else, but recognizing those very sources of error in themselves and in the groups to which they belong, they have devised elaborate systems to tie their own hands, forcibly preventing their frailties and prejudices from infecting their results.

Scientists make mistakes. Accordingly, it is the job of the scientist to recognize our weakness, to examine the widest range of opinions, to be ruthlessly self-critical. Science is a collective enterprise with the error-correction machinery often running smoothly.

As much as I loved the ideas, I excelled at experimental failure, I found new ways to make experiments not work. I would mess up PCRs, add the wrong buffers, northerns, westerns, southerns. I would make them not work in quite ingenious ways, and I realized slowly, over the course of those years, that the secret to being a great scientist is to love the manual labor of it.

The fact that a great many scientists signed Faustian pacts with the war devil throughout the twentieth century has given science a bad name, and has discouraged many able youngsters from pursuing a scientific career.