Y así, del poco dormir y del mucho leer, se le secó el cerebro, de manera que vino a perder el juicio.

Finally, from so little sleeping and so much reading, his brain dried up and he went completely out of his mind.

And thus, from too little sleep and too much reading, his brain dried up and he completely lost his judgment.

with little sleep and much reading his brains got so dry that he lost his wits.

"it was like this. the brain could no longer bear the worries and pains that were imposed on it. it said: "i'm giving up; but if there is anyone else here who is interested in preserving the whole, let him assume part of my burden and it will be alright for a bit.

É assim, do pouco dormir e do muito ler se lhe secou o cérebro, de maneira que chegou a perder o juízo.

...he spent whole days and nights over his books; and thus with little sleeping and much reading his brains dried up to such a degree that he lost the use of his reason.

Without being too clinical, let’s say his brain was affected.

Como se ve, aquella cabeza, tan serena y fría hasta entonces, atravesaba un periodo de extravío lamentable, de delirio completo.

El hombre tenía tal entendimiento que ya casi no servía para nada.

Disgusting as he usually was, on rare occasions he showed flashes of stagnant intelligence. But his brain was so rotted with drink and dissolute living that whenever he put it to work it behaved like an old engine that had gone haywire from being dipped in lard.

He unzipped his pants and his brains fell out.

He was in a terrible state- that of consciousness.

Sleep slunk up like a black panther and sank its kindly fangs into what remained of the Mortdecai brain.