There is not a single effect in Nature, not even the least that exists, such that the most ingenious theorists can ever arrive at a complete understa… - Galileo Galilei

This vain presumption of understanding everything can have no other basis than never understanding anything.

I cannot sufficiently admire the eminence of those men's wits, that have received and held it to be true, and with the sprightliness of their judgments offered such violence to their own senses, as that they have been able to prefer that which their reason dictated to them, to that which sensible experiments represented most manifestly to the contrary. ...I cannot find any bounds for my admiration, how that reason was able in Aristarchus and Copernicus, to commit such a rape on their senses, as in despite thereof to make herself mistress of their credulity.

Nature first made things in
her own way, and then made human reason skillful enough to be able to understand, but
only by hard work, some part of her secrets.

About five years ago I was engaged in preparing a catalogue of the ancient books which belong to Christ’s Hospital.