I do not think there is any thrill that can go through the human heart like that felt by the inventor as he sees some creation of the brain unfolding to success . . . Such emotions make a man forget food, sleep, friends, love, everything.

"Holger Hyden discovers that the brain cells of educated rats contain a third more RNA the those of uneducated rats.
University of California psychologists pass on learning from one rat to another by injecting RNA from trained rats.
Neurologists are "wiring up" the brains of animals and men and altering consciousness by pressing buttons. Press a button - make him hungry. Press a button - make him horny. Press a button - make him angry. Press a button - make him happy.
The psychedelic chemicals flood out of the laboratories. Into the hands of the two familiar groups; those who want to do something to others for
power and control; those who want to do something to themselves for fun and love."

What are these substances? Medicines or drugs or sacramental foods? It is easier to say what they are not. They are not narcotics, nor intoxicants, nor energizers, nor anaesthetics, nor tranquilizers. They are, rather, biochemical keys which unlock experiences shatteringly new to most Westerners. For the last two years, staff members of the Center for Research in Personality at Harvard University have engaged in systematic experiments with these substances. Our first inquiry into the biochemical expansion of consciousness has been a study of the reactions of Americans in a supportive, comfortable naturalistic setting. We have had the opportunity of participating in over one thousand individual administrations. From our observations, from interviews and reports, from analysis of questionnaire data, and from pre- and postexperimental differences in personality test results, certain conclusions have emerged. (1) These substances do alter consciousness. There is no dispute on this score. (2) It is meaningless to talk more specifically about the “effect of the drug.” Set and setting, expectation, and atmosphere account for all specificity of reaction. There is no “drug reaction” but always setting-plus-drug. (3) In talking about potentialities it is useful to consider not just the setting-plus-drug but rather the potentialities of the human cortex to create images and experiences far beyond the narrow limitations of words and concepts. Those of us on this research project spend a good share of our working hours listening to people talk about the effect and use of consciousness-altering drugs. If we substitute the words human cortex for drug we can then agree with any statement made about the potentialities — for good or evil, for helping or hurting, for loving or fearing. Potentialities of the cortex, not of the drug. The drug is just an instrument. In analyzing and interpreting the results of our studies we looked first to the conventional models of modern psychology —

The human mind is capable of excitement without the application of gross and violent stimulants; and he must have a very faint perception of its beauty and dignity who does not know this.

The human mind is capable of excitement without the application of gross and violent stimulants; and he must have a very faint perception of its beauty and dignity who does not know this...

With the arrival of electric technology, man has extended, or set outside himself, a live model of the central nervous system itself. To the degree that this is so, it is a development that suggests a desperate suicidal autoamputation, as if the central nervous system could no longer depend on the physical organs to be protective buffers against the slings and arrows of outrageous mechanism.

The brain can be made to drug itself, as seems to happen with certain placebos. We don’t merely imagine that the placebo antidepressant is working to life our sadness or worry—the brain is actually producing extra serotonin in response to the mental prompt of swallowing a pill containing nothing but sugar and belief. What all this suggests is that the workings of consciousness are both more and less materialistic than we usually think: chemical reactions can induce thoughts, but thoughts can also induce chemical reactions.

Thus the “brainy” economy designed to produce this happiness is a fantastic vicious circle which must either manufacture more and more pleasures or collapse — providing a constant titillation of the ears, eyes, and nerve ends with incessant streams of almost inescapable noise and visual distractions. The perfect “subject” for the aims of this economy is the person who continuously itches his ears with the radio, preferably using the portable kind which can go with him at all hours and in all places. His eyes flit without rest from television screen, to newspaper, to magazine, keeping him in a sort of orgasm-with-out-release through a series of teasing glimpses of shiny automobiles, shiny female bodies, and other sensuous surfaces, interspersed with such restorers of sensitivity — shock treatments — as “human interest” shots of criminals, mangled bodies, wrecked airplanes, prize fights, and burning buildings. The literature or discourse that goes along with this is similarly manufactured to tease without satisfaction, to replace every partial gratification with a new desire. For this stream of stimulants is designed to produce cravings for more and more of the same, though louder and faster, and these cravings drive us to do work which is of no interest save for the money it pays — to buy more lavish radios, sleeker automobiles, glossier magazines, and better television sets, all of which will somehow conspire to persuade us that happiness lies just around the corner if we will buy one more. Despite the immense hubbub and nervous strain, we are convinced that sleep is a waste of valuable time and continue to chase these fantasies far into the night. Animals spend much of their time dozing and idling pleasantly, but, because life is short, human beings must cram into the years the highest possible amount of consciousness, alertness, and chronic insomnia so as to be sure not to miss the last fragment of startling pleasure. It isn’t that the people who submit to this ki

But is this wonder the real thing? At first glance, it wouldn’t seem to be: a transcendence that’s chemically induced must surely be fake. Artificial Paradises was what Charles Baudelaire called his 1860 book about his experiences with hashish, and that sounds about right. Yet what if it turns out that the neurochemistry of transcendence is no different whether you smoke marijuana, meditate or enter a hypnotic trance by way of chanting, fasting, or prayer? What if in every one of these endeavors, the brain is simply prompted to produce large quantities of cannabinoids, thereby suspending short-term memory and allowing us to experience the present deeply?…From a brain’s point of view, the distinction between a natural and an artificial high may be meaningless.

The professional and financial interest in continuing animal experimentation helps to explain at least some resistance to the notion that animals have a complex emotional life and are capable of experiencing the higher emotions, such as love, compassion, altruism, disappointment and nostalgia. To acknowledge such a possibility implies certain moral obligations. If chimpanzees can experience loneliness and mental anguish, it becomes more wrong to use them for experiments in which they are isolated and anticipate daily pain.

Addictive drugs misuse the brain’s existing pre-programming, activating reward mechanisms and extreme feelings of pleasure. When stimulated, the brain’s pleasure centres emit signals to repeat the behaviour. In this sense, the brain is pre-programmed to feel good.

If you take the activation at different levels of these networks and you... enhance this activation a little... you get stuff that looks very psychadelic, which might be similar to what happens if you put certain illegal substances into people and enhance the activity on certain layers of their visual processing.

There are... otherwise quite decent people who are so dull of nature that they believe that they must attribute the swift flight of fancy to some illness of the psyche, and thus it happens that this or that writer is said to create not other than while imbibing intoxicating drink or that his fantasies are the result of overexcited nerves and resulting fever. But who can fail to know that, while a state of psychical excitement caused by the one or other stimulant may indeed generate some lucky and brilliant ideas, it can never produce a well-founded, substantial work of art that requires the utmost presence of mind.

Human nature has in the past put certain limits on the development of societies. People could be pushed only so far and no farther. But today this may be changing, because modern technology is developing ways of modifying human beings. Imagine a society that subjects people to conditions that make them terribly unhappy, then gives them drugs to take away their unhappiness. Science fiction? It is already happening to some extent in our own society. It is well known that the rate of clinical depression has been greatly increasing in recent decades. Instead of removing the conditions that make people depressed, modern society gives them antidepressant drugs. In effect, antidepressants are a means of modifying an individual's internal state in such a way as to enable him to tolerate social conditions that he would otherwise find intolerable.