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It is unworthy of excellent men to lose hours like slaves in the labour of calculation which could safely be relegated to anyone else if machines were used.

(Describing, in 1685, the value to astronomers of the hand-cranked calculating machine he had invented in 1673.)

This interconnection or accommodation of all created things to each other, and each to all the others, brings it about that each simple substance has relations that express all the others, and consequently, that each simple substance is a perpetual, living mirror of the universe.

Nature has established patterns originating in the return of events, but only for the most part. New illnesses flood the human race, so that no matter how many experiments you have done on corpses, you have not thereby immposd a limit on the nature of events so that in the future they could not vary.